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Which Way is the CIRM IP Task Force Heading On Stem Cell Research?

A post by David Jensen in (iii) maintains the potential to
californiastemcellreport on April 25 had differentiate into derivatives of
some quotes relevant to CIRM's IP endoderm, mesoderm, and ectoderm tissues
(intellectual property) Task Force throughout the culture, and
meeting in March 2006 and to a meeting (iv) will not differentiate when
schedulued for San Diego on Thursday, cultured on a fibroblast feeder
April 27.--> Ed Penhoet, chair of the layer.First claim of US 6,200,806 (the
task force, said last month's hearing application leading to the '806 patent
raised some fundamental questions."What was a divisional of the application
are we really attempting to do? Are we leading to the '780 patent) :A purified
trying to drive therapies as rapidly as preparation of pluripotent human
possible? Are we trying to stimulate embryonic stem cells which(i) will
business in California? Do we want to proliferate in an in vitro culture for
grow small companies? There (is) a whole over one year,
set of potentially conflicting aims," (ii) maintains a karyotype in which the
Penhoet said.As a comment, one notes the chromosomes are euploid and not altered
CIRM people need to get their act through prolonged culture,
together to spend their money in a (iii) maintains the potential to
coherent manner, and not have conflicting differentiate to derivatives of endoderm,
aims. It's one thing if this is a WPA mesoderm, and ectoderm tissues throughout
project for biologists; it's another the culture, and
thing if one is trying to get royalties (iv) is inhibited from differentiation
from patents, and it's still another when cultured on a fibroblast feeder
thing to focus on getting a useful layer.Looking carefully, one will note
product to market. The WPA project model that the basic preparation (first line)
is the easiest to accomplish ("we spent a and all elements (i-iv) are different
lot of money in an important area and between the basic claims of the two
employed lots of scientists") but is most patents. For someone to get the type of
likely to lead to disappointment.--> patent protection to encourage the
Brad Margus, CEO of Perlegen Sciences of investment to bring a product to market,
Mountain View, Ca., told the task force the person will need to get a broad
that if CIRM wants to be an agent that claim, one that is not limited to the
produces the next big thing in stem specific patient who will be the
cells, it needs to minimize nonfinancial recipient of the "patient-specific" stem
restrictions and heavy royalties."I'd cells. This need is apt to foster a
like California to try to do it patent-thicket problem.Geron has
differently ....and think a little exclusive rights in the Thomson patents
smarter. If there really is a company out in certain areas. For investment, Geron
there that has the next thing that you has sought private investors, largely
need in stem cell research to happen, and ignoring the Congressional debates over
your objective scientific advisors say expanding federal research dollars and
this is what we want, you should be the vast bureaucracy that has held up
really, really aggressive in getting it. state funding in California. "Given their
And I'm concerned that some of these financial acumen, they are pretty much
things that we're throwing out there, self-sustaining for the foreseeable
like revenue sharing or the capping what future," says Steve Brozak, an analyst at
a company (can earn), will only defeat WBB Securities, a brokerage based in San
that purpose."As a comment, one "next big Diego. "They've managed that by tapping
thing in embryonic stem cells" is to do into the capital markets. These folks
what Hwang Woo-Suk claimed to have done have learned very well; they don't want
in 2005: create patient specific to be caught at the mercy of anybody."
embryonic stem cell lines. All the Geron has spent about $100 million in
"objective science advisors" in the world stem cell research over the last 10
failed to counsel anyone that Hwang's years, small in comparison to
work was fraudulent, so one has to take California's potential of $3 billion over
advice in this area with a grain of salt. the next 10 years. Geron announced it
Beyond doing patient-specific stem expects to file for permission from the
cells, one still needs to use such things Food and Drug Administration [FDA] to
in some beneficial way to actually help begin trials for an
human beings. That objective may be more embryonic-stem-cell-based therapy for
than 10 years in the future. Most venture spinal-chord injuries this year.
capitalists seem to think the time line [information and quote from
for a real product is long.--> One smartmoney.com] Keep in mind, under 35
executive from Genentech, which has only USC 271(e)(1) as interpreted in the Merck
a peripheral stem cell interest, told the v. Integra case, anyone is pretty much
task force that it takes something like free to infringe anyone else's patents
$1 billion to push a product to market. for purposes of obtaining information
He said that for every dollar in needed by the FDA.The Washburn article
research, another $5 is need for was discussed in a previous ezine piece:
development. And the odds of developing a Ebert, Lawrence. (2006, April 12). Los
successful product once it starts Angeles Times Article Way Off Base on
clinical testing on humans range from one Stem Cell Issues. EzineArticles.
in three to one in five.As a comment, one Retrieved April 27, 2006, from
has to be careful to note that an reluctance of venture capitalists to
effective business model for invest in stem cell research is discussed
patient-specific stem cells (geared to in an ezine piece: Ebert, Lawrence.
INDIVIDUALS) is apt to be different from (2006, April 24). MIT Technology Review
a business model for blockbuster drugs Concern Over WARF Patent Royalty Demand
(geared to MANY PEOPLE taking the SAME To CIRM Over Stem Cells Is Misguided.
drug).As some guidance, one can EzineArticles. Retrieved April 27, 2006,
contemplate the basic composition of from B. Ebert is a registered patent
matter claims of the Thomson/WARF attorney located in central New Jersey.
patents, recently strongly criticized by He holds a Ph.D. from Stanford, a J.D.
Washburn in the Los Angeles Times.First from the University of Chicago, maintains
claim of US 5,843,780:A purified a blog at IPBiz.blogspot.com, and is the
preparation of primate embryonic stem author of LESSONS TO BE LEARNED FROM THE
cells which(i) is capable of HWANG MATTER: ANALYZING INNOVATION THE
proliferation in an in vitro culture for RIGHT WAY, published in the Journal of
over one year, the Patent & Trademark Office Society [88
(ii) maintains a karyotype in which all JPTOS 239 (March 2006)]. Ebert is listed
the chromosomes characteristic of the in Marquis Who's Who in America, Diamond
primate species are present and not Edition, 2005. Ezine draft submitted
noticeably altered through prolonged April 27, 2006.
culture,




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